methyl benzothiophene-2-carboxylate

methyl benzothiophene-2-carboxylate - Names and Identifiers

Name	Methyl benzo(b)thiophene-2-carboxylate
Synonyms	AKOS 91623 RARECHEM AL BF 0483 Methyl Benzothiophene Carboxylate methyl benzothiophene-2-carboxylate Methyl benzo[b]thiophene-2-carboxylate Methyl benzo(b)thiophene-2-carboxylate Benzothiophene-2-Carboxylic Acid Methyl Ester Benzo(b)thiophene-2-cyrboxylic acid methylester BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER Benzo[b]thiophene-2-carboxylicacidmethylester~Methylthianaphthene-2-carboxylate~Thianaphthene-2-carboxylicacidmeth Benzo[b]thiophene-2-carboxylic acid methyl ester~Methyl thianaphthene-2-carboxylate~Thianaphthene-2-carboxylic acid methyl ester
CAS	22913-24-2
EINECS	625-266-0
InChI	InChI=1/C10H8O2S/c1-12-10(11)9-6-7-4-2-3-5-8(7)13-9/h2-6H,1H3

methyl benzothiophene-2-carboxylate - Physico-chemical Properties

Molecular Formula	C10H8O2S
Molar Mass	192.23
Density	1.273±0.06 g/cm3(Predicted)
Melting Point	70-74°C
Boling Point	304.6±15.0 °C(Predicted)
Flash Point	138.009°C
Vapor Presure	0.001mmHg at 25°C
BRN	142166
Storage Condition	2-8°C
Refractive Index	1.638
MDL	MFCD00067791

methyl benzothiophene-2-carboxylate - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

methyl benzothiophene-2-carboxylate - Reference Information

application

methylbenzothiophene-2-formaldehyde is an organic synthesis intermediate, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis, and can be obtained by esterification of benzothiophene-2-formic acid. It can be used to synthesize 2-substituted -1,3, 4-oxadiazinone compounds-compound 4.

preparation

14.25g (80 mmol) indole -2-formic acid is dissolved in 500 mL methanol, 2 mL concentrated sulfuric acid is added, reflux reaction is carried out at 75 ℃ for 24 h, TLC (5% water-acetonitrile) monitors the reaction process. after the reaction is completed, most of the solvent is evaporated under reduced pressure, the solution was cooled and let stand at 0 ℃ for about 10 h, needle crystals were precipitated, and 15.36g of methyl benzothiophene-2-formate (1) was obtained by filtration with a yield of 93%.

Last Update：2024-04-09 20:52:54